NAD+
Nicotinamide adenine dinucleotide
The oxidised cofactor itself, not a precursor. Supplied at ≥ 99 % with residual nicotinamide reported, because hydrolysis is the failure mode that matters here.
Current lot verified
CP-NADPLUS-2607A · tested Jul 12, 2026
99.64 %
HPLC purity
About NAD+
NAD+ is a dinucleotide cofactor central to redox metabolism and the obligatory substrate for the sirtuin and PARP enzyme families. Unlike the precursors that dominate the consumer market, this is the cofactor in its active oxidised form, which is what cell-free enzymatic assays actually require.
The quality problem specific to NAD+ is hydrolysis. The glycosidic bond degrades to nicotinamide and ADP-ribose on exposure to moisture, heat or alkaline pH, and a partially hydrolysed lot assays as a weaker cofactor while looking fine to casual inspection. Nicotinamide is also a direct sirtuin inhibitor, so a hydrolysed lot does not merely underperform — it actively confounds sirtuin work. We report residual nicotinamide as a separate line on the certificate and ship with desiccant and a cold pack as standard.
Published research areas
- Sirtuin enzymology
- PARP activity assays
- Cellular redox metabolism
- Mitochondrial function studies
Specifications
- CAS number
- 53-84-9
- Molecular formula
- C21H27N7O14P2
- Molecular weight
- 663.43 g/mol
- Release specification
- ≥ 99.0 % by HPLC
- Appearance
- White to pale yellow lyophilised powder
- Solubility
- Freely soluble in water; solutions are acidic and should be used promptly
- Storage
- -20 °C, desiccated. Hygroscopic — reseal immediately after opening.
- Format
- lyophilized vial
Handling and reconstitution
Prepare fresh. Aqueous NAD+ hydrolyses measurably within days even refrigerated, and the hydrolysis product inhibits sirtuins.
Storage: -20 °C, desiccated. Hygroscopic — reseal immediately after opening.
Full reconstitution and storage referenceLot history
Every released lot of this compound, oldest kept on file. Average across 3 lots: 99.61 %.
| Lot | Strength | Purity | Tested | Laboratory | |
|---|---|---|---|---|---|
| CP-NADPLUS-2607A | 100 mg | 99.64 % | Jul 12, 2026 | Aurum Bioanalytics | Certificate → |
| CP-NADPLUS-2604B | 500 mg | 99.56 % | Apr 30, 2026 | Janoshik Analytical | Certificate → |
| CP-NADPLUS-2603C | 1000 mg | 99.63 % | Mar 14, 2026 | Janoshik Analytical | Certificate → |
Questions about this compound
Nicotinamide is a direct sirtuin inhibitor. A lot with elevated residual nicotinamide will not just give you less cofactor, it will actively suppress the enzyme activity you are trying to measure. We report it as a distinct assay line rather than folding it into a single purity number.
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